Bile is a digestive fluid secreted by the liver and stored in the gallbladder which normally is released into the duodenum portion of the small intestine through the sphincter of Oddi. Bile, released after a meal containing fats, aids in absorption and digestion of the fat.
Biliary obstruction occurs when the duct which transports bile from the liver to the small intestine (duodenum) is blocked by a stone, a tumor, an injury or inflammation of any of the ducts. A tumor in the pancreas may press in on the ducts, causing a backup of bile in the gallbladder. Blood tests may indicate a high level of bilirubin, a waste product of the liver, or diagnosis may come from an endoscopic examination. Untreated biliary obstruction may cause life-threatening infection or chronic liver disease.
One method of relieving a blockage of the bile duct due to pancreatic tumors is the placement of a stent, a device designed to hold tube-shaped structures open. An endoscope (an instrument placed down the throat into the esophagus, through the stomach to the duodenum of the small intestine) helps the surgeon to see the blockage and to place the stent in the correct position. Dye may be injected and X-ray images taken to insure the stent is correctly placed and the flow of bile is restored.
Once the flow of bile is restored, the threat of infection and inflammation is decreased. However, the prognosis may not be significantly altered if the pancreatic carcinoma is otherwise untreatable. Reoccurrence of the blockage (restenosis) may also occur, requiring further surgery or replacement of the stent.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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